Witnesses say a man armed with an axe started hitting people with the weapon at the train station.
Those injured were not in a life-threatening condition, the police spokesman said.
According to reports in the German press, at least five people were wounded; the extent of their injuries were not yet known. However so far police have not given any indication as to the motivation or identities of those involved.
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Two suspects are believed to have been detained by police but the motive for the attack is now unknown.
Terrified passengers took to social media to say the situation inside the station "looked bad" shortly after the attack.
"Man with axe chased by police in Dusseldorf".
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"We were standing on the track, waiting for the train", a station attendant told the German newspaper Bild.
Germany is in a high state of alert after suffering a year of frequent, gruesome terror attacks.
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