World number one Murray, a five-time champion at Queen's and the reigning Wimbledon title-holder, was left stunned by the Australian - a late replacement for the injured Aljaz Bedene - winning his first match against a top-10 opponent.
Rising Thompson, who lost in the final round of Queen's qualifies, will be meeting next big-serving Sam Querrey. This tournament has given me great preparation in the past, and when I have won here Wimbledon has tended to go pretty well, too, ' said Murray.
"There are no guarantees that I won't do well at Wimbledon, but it certainly would have helped to have had more matches".
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Murray also played in a fund-raising match at the end of that year's tournament with his coach, Ivan Lendl, Tim Henman and Tomas Berdych.
The two-time Wimbledon champion is now gearing up to defend his title at Queen's Club, with his opening match taking place today against Aljaž Bedene.
"I do think that a lot can change in a short period of time".
Murray put in a sloppy and error-prone display against the 90th-ranked Thompson, joining Wawrinka and Milos Raonic in getting eliminated on a day of shocks at the Wimbledon warmup event.
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Thompson, 23, made it through as a lucky loser, but there was nothing fortunate about his win over five-times Queen's victor Murray, who was blighted by a severe lack of consistency at the London warm-up event. "I just wanted to enjoy myself and stay calm". He and Murray have never previously met. I trained a lot Monday to Thursday and then I was playing practice sets.
Thompson, who has lost all four of his previous grass-court matches, struck 12 aces and saved all three break points he faced to hand Murray his first opening-round loss at Queen's Club since 2006.
He admitted: "I won't win Wimbledon if I play like that - but I can play better than that".
2014 runner-up Lopez hit 18 ace shots, won 83 percent of his first serve points and saved Wawrinka's two break chances in an hour and a half of action.
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