The games will mark the onset of a long summer for the Indian team, with sterner tests against England to follow this short series in Malahide on the outskirts of Dublin.
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Nevertheless, Raina provides a sixth bowling option as well.
India - who will now head off to England for three T20Is, three ODIs and five Tests - topped 200 back-to-back for the first time in the format after following Wednesday's 208-5 with 213-4 and then skittled Ireland for just 70 in 12.3 overs to earn the joint-second biggest win in the history of T20Is. However, India know that Ireland are no knock-overs. It could mean that Pandey eventually warms the bench.
Wrist-spinners Kuldeep Yadav and Yuzvendra Chahal snared seven wickets between them in Wednesday's win and are expected to retain their place for the clash.
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Going into the second match, Kohli had hinted at making a few changes in the middle order to give everyone game-time so they could acclimatise to the conditions. He played only 4 dot balls in the innings. Kohli has stuck to his words and made as many as four changes in the playing eleven.
It's a rare occasion when the former Indian skipper had to sit out despite being in the squad. Joshua Little, 18, is a left-arm fast bowler who has played only four T20s so far - two of them T20Is - and was part of the Ireland team in the Under-19 World Cup in New Zealand in January 2018.
Ireland likely XI for 2nd T20I: Paul Stirling, James Shannon, Andy Balbirnie, Simi Singh, Gary Wilson (c), Kevin O'Brien, Stuart Poynter (wk), Andy McBrine, George Dockrell, Boyd Rankin, Peter Chase.
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Panama will look to their superstar Roman Torres who Captains the side and scored the goal that got them to the World Cup . If we keep the ball, keep to the style we've been playing, I think we'll be fine".
Suresh Raina played the supporting role, scoring 69 off 45 balls, as the two put together a 106-run stand for the second wicket.