It took until only the second round for Lomachenko to open up and hit his stride offensively.
Lomachenko, 31, defended his WBO and WBA lightweight titles, against heavy underdog Crolla, 32.
"Lomachenko was too good for Anthony", he said.
"I know I will have to put up with being frustrated by him".
Lomachenko (13-1, 10 KOs) brutalized the mandatory challenger for his WBA belt throughout their brief fight, and the Ukrainian almost ended it late in the third round when he knocked Crolla into the ropes.
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"I think they [should have] throw the towel in, but it is, what it is". "I always need to find a key for his defense".
Campbell could be a potential opponent for Lomachenko as he has earned a mandatory shot at the WBC title now held by Mikey Garcia, who is yet to announce if he will vacate the belt.
Lomachenko appeared to injure his hand and was seen holding it and talking to his trainer after the fight.
Crolla dropped to 34-7-3 after a poor performance against overwhelming favourite Lomachenko. Nothing got better in the fourth, and Lomachenko hurt Crolla before finishing him in dramatic fashion. Losing to Lomachenko is never a disgrace.
Lomachenko headlined at Staples Center for the first time in his brief professional career.
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CBS Sports was with you for every punch from the bout in Los Angeles with our updating scorecard and live updates below.
'I feel at home here, ' Lomachenko said. "I feel like I'm in Ukraine here".
His profile has grown after headlining at Madison Square Garden and other LA venues before stepping up to Staples.
But he faces a mammoth task against Lomachenko, one of the sport's most dominant fighters. But as I alluded to earlier, the mandatory challenge was essentially the last of Vasyl's sanctioned requirements before he unifies the lightweight crown in a winner-takes-all contest with Mikey Garcia. Both Lomachenko and the California commission members thought the fight had been stopped and began to celebrate and enter the ring until Reiss restored order.
LA celebrities in attendance included Don Cheadle, Rosie Perez, director Peter Berg and Los Angeles Rams coach Sean McVay.
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